AI clinical trial finder / Alzheimer's and dementia

AI clinical trials in Alzheimer's and dementia: open or opening soon

68 studies that use artificial intelligence or machine learning and are recruiting or about to recruit, from ClinicalTrials.gov (updated 2026-11-05).

Before you contact a study: a listing here is not a recommendation. Check the eligibility criteria and contacts on the official ClinicalTrials.gov page, and discuss any trial with your own doctor. Taking part is voluntary, and you can usually leave a study at any time.

Most common countries with study sites

United States (13)Italy (12)China (9)Canada (4)France (4)United Kingdom (4)Taiwan (3)Switzerland (2)Singapore (1)Brazil (1)Hong Kong (1)United Arab Emirates (1)Denmark (1)Israel (1)Germany (1)

Studies

Study	Status	Type	Countries	Start
Tailored Brain Health Insights Through Nurturing Knowledge-based Change - Stakeholder-driven, Human-centered, AI-powered Refinement for Prevention NCT07612800 · Alexandra Hospital	Not yet recruiting	Interventional	Singapore	2026-12
Automated Language Analysis in Neurodegenerative Diseases: Application of Artificial Intelligence Models NCT07906769 · Istituti Clinici Scientifici Maugeri SpA	Recruiting	Interventional	Italy	2025-10
The Efficacy of an IADL-based Non-immersive Virtual Reality Training Program to Enhance ADL Performance and Cognitive Function for Persons at Risk of Dementia NCT07895979 · National Taiwan University Hospital	Recruiting	Interventional	Taiwan	2026-02
Use of Wearables for Identifying Factors Associated With Mild Cognitive Impairment and Early-Stage Alzheimer's Disease NCT07391436 · Getúlio Vargas University Hospital	Recruiting	Observational	Brazil	2026-03
Remote Digital Assessments for Cognitive Disorders NCT07883746 · Centre for Addiction and Mental Health	Not yet recruiting	Observational	Canada	2026-11
A Prospective Cohort Study of Multimodal Biomarkers and Progression From Mild Cognitive Impairment to Dementia NCT07876570 · Xuanwu Hospital, Beijing	Recruiting	Observational	China	2026-01
Development of Eye-movement Based Biomarkers in Alzheimer's Disease NCT05176704 · McGill University	Recruiting	Observational	Canada	2026-05
Machine Learning Enabled Management of Behavioural and Psychological Symptoms of Dementia Intervention for Dementia Caregivers NCT07444866 · Education University of Hong Kong	Not yet recruiting	Interventional	Hong Kong	2026-10
A Study of Retinal Imaging to Detect Abnormal Protein Deposits Associated With Alzheimer's Disease NCT07254234 · Eli Lilly and Company	Recruiting	Observational	United Arab Emirates	2026-09
The BRAIN App (Phase 2 SBIR) NCT06298474 · Hopeful Aging	Recruiting	Interventional	United States	2025-05
Speech-Based Artificial Intelligence for Detection of Dementia in Danish Patients (DetectAI) NCT07200739 · Zealand University Hospital	Not yet recruiting	Observational	Denmark	2026-11
Neurodegenerative Diseases Progression Markers (MARKERS-NDD) NCT06596746 · Casa di Cura San Raffaele Cassino	Recruiting	Observational	Italy	2024-09
AI-CONECT: A Conversational AI for Early Dementia Prevention in Socially-Isolated Older Adults NCT07701668 · Massachusetts General Hospital	Not yet recruiting	Interventional	United States	2026-10
MECHANISMS OF NEURONAL RESILIENCE IN ALZHEIMER'S DISEASE AND ITS FOCAL VARIANTS: A PET/MR STUDY NCT04150198 · Institut National de la Santé Et de la Recherche Médicale, France	Recruiting	Interventional	France	2021-12
Developing and Testing an AI-Based Cognitive Intervention Program NCT07766993 · National Research Center for Rehabilitation Technical Aids	Not yet recruiting	Interventional	not listed	2026-11
LLM-Driven Daily Conversation for Cognitive Health in Older Adults NCT07751510 · Taipei Medical University Shuang Ho Hospital	Not yet recruiting	Interventional	not listed	2026-09
Digital Solutions for Predicting the Biological Mechanisms of Alzheimer's Disease Through the Analysis of Risk Factors NCT07731191 · IRCCS Centro San Giovanni di Dio Fatebenefratelli	Recruiting	Interventional	Italy	2026-06
Transcranial Magnetic Stimulation for Alzheimer's Disease Treatment NCT03121066 · Universitat Oberta de Catalunya	Not yet recruiting	Interventional	not listed	2027-11
Home-Based Brain Stimulation for Motoric Cognitive Risk Syndrome NCT06821568 · Hebrew SeniorLife	Recruiting	Interventional	Israel, United States	2025-09
Brain Wave Informed Non-invasive Brain Stimulation: Improving Neural Networks of Working Memory in Dementia: a Proof-of-concept Study NCT07673770 · McMaster University	Recruiting	Interventional	Canada	2026-07
Deep Learning on Amyloid Positons Emission Tomography NCT07309107 · Central Hospital, Nancy, France	Recruiting	Observational	France	2026-05
Using Artificial Intelligence to Detect Early Signs of Alzheimer's Disease in People With Memory Concerns NCT07652931 · IRCCS San Raffaele	Not yet recruiting	Interventional	Italy	2026-08
Italian Validation of the dNA Scale and Its Correlation With Neurocognitive Variables NCT07533084 · Neuromed IRCCS	Not yet recruiting	Observational	Italy	2026-09
Effects of Binaural Beats and Spatialized Music on Behavioural and Psychological Symptoms of Dementia in Assisted Living Facility Residents NCT07626944 · Maharishi International University	Recruiting	Interventional	United States	2026-05
Management of Age-Related Auditory Decline and Early Warning of Its Co-occurring Dementia NCT07608640 · Chinese PLA General Hospital	Not yet recruiting	Observational	China	2026-05
Multi-modal Large Language Model-Empowered Talk Therapy for Older Adults With ADRD NCT07499570 · Indiana University	Recruiting	Interventional	United States	2025-09
PARO-agitation-study NCT07568093 · Hannover Medical School	Recruiting	Interventional	Germany	2025-12
Large Language Model for Understanding and Monitoring Elderly Neurocognition NCT07347431 · Northumbria Healthcare NHS Foundation Trust	Recruiting	Observational	United Kingdom	2026-03
Ultralow Dose PET Imaging of 18F-Florbetapir, 18F-Flutemetamol NCT07012993 · Akiva Mintz	Recruiting	Interventional · Phase 2	United States	2025-05
Effects of Real vs. Soundless Acoustic Stimulation During Deep Sleep on Brain Activity, Memory, and Blood Biomarkers in Older Adults (60-85) With Mild Memory Impairment NCT06669546 · University of Bern	Recruiting	Interventional	Switzerland	2025-02
Early Detection of Alzheimer's Disease and Affective Disorders by Automated Voice and Speech Analysis (PLATA) NCT05943834 · Centre Hospitalier Universitaire de Nice	Recruiting	Observational	France	2023-07
Precision Medicine and Neurodegenerative Diseases: Advanced Systems for the Diagnosis and Treatment of Parkinson's Disease and Alzheimer's Disease. NCT07467460 · Neuromed IRCCS	Recruiting	Observational	Italy	2026-02
Testing & Refinement of CarePair: An Assessment and Referral Platform to Support Family Caregivers of Alzheimer's Disease and Related Dementias. NCT06418971 · University of Southern California	Recruiting	Interventional	United States	2025-09
Generation of Synthetic [18F]FDG PET From Early-Phase Amyloid PET in Alzheimer's Disease NCT07431255 · IRCCS San Raffaele	Not yet recruiting	Observational	Italy	2026-03
RCT of HeartBot in Women NCT07416734 · University of California, San Francisco	Not yet recruiting	Interventional	United States	2026-03
The Signature of Alzheimer's Disease in Subjective Cognitive Decline NCT07402161 · IRCCS Policlinico S. Donato	Recruiting	Observational	Italy	2025-10
AI4HOPE Pilot Study 1 Digital Toolkit Assessment NCT06289322 · University of Bonn	Not yet recruiting	Interventional	not listed	2026-02
AI4HOPE Pilot Study 2 Digital Dementia Care Planning NCT06292143 · University of Bonn	Not yet recruiting	Interventional	not listed	2026-02
LETHE-AT: a Personalized Multidomain Lifestyle Intervention for Individuals at Increased Risk of Memory Impairment. NCT07376135 · Medical University of Vienna	Not yet recruiting	Interventional	Austria	2026-01
Clinical Validation of AI-powered Smart Vehicle Assisted Gait Training in Neurodegenerative Disorders NCT07230366 · Taipei Medical University Shuang Ho Hospital	Not yet recruiting	Interventional	Taiwan	2026-01
Vascular mEchanisms in, Stroke, dePression, dementiA, and deliRum: The VESPAR Project NCT05649800 · University of Leicester	Recruiting	Observational	United Kingdom	2023-03
Virtual Reality Intervention for Family Caregivers of Persons Living With Dementia NCT07248345 · Chang Gung Memorial Hospital	Not yet recruiting	Interventional	not listed	2026-06
Passive Sensor Identification of Digital Biomarkers to Assess Effects of Orally Administered Nicotinamide Riboside NCT05245903 · Mclean Hospital	Recruiting	Observational	United States	2022-05
Benefits of Personalised Music in Dementia - a Feasibility Study NCT04132362 · Music for my Mind	Recruiting	Observational	United Kingdom	2019-11
Remote Sensing for ADRD-Specific Activities Identification in Older Adults NCT07120347 · University of Missouri-Columbia	Recruiting	Interventional	United States	2024-08
Smartphone Multimodal Health Intervention for Neurological Enhancement (SHINE) NCT07092371 · Second Affiliated Hospital, Zhejiang University, School of Medicine	Not yet recruiting	Interventional	China	2025-08
The Clinical Study of Synaptic Plasticity-based Lencanumab for the Treatment of Early Alzheimer's Disease NCT06871839 · Cuibai Wei，Clinical Professor	Recruiting	Observational	China	2025-03
The COMFORTage Project at Ace Alzheimer Center Barcelona NCT07031167 · Fundació ACE Institut Català de Neurociències Aplicades	Not yet recruiting	Interventional	Spain	2025-07
AI-Driven Personalization of End-of-Life Care for the Elderly NCT07027618 · Baqiyatallah Medical Sciences University	Not yet recruiting	Interventional	not listed	2025-07
Application of AI Technology for the Diagnosis and Treatment of Geriatric Diseases NCT06295263 · Qilu Hospital of Shandong University	Recruiting	Observational	China	2022-03
AI-Enhanced Optimization of Acute Levodopa Challenge Test NCT06949865 · Beijing Tiantan Hospital	Recruiting	Observational	China	2024-05
Optical Neuroimaging and Cognition NCT05460143 · University of Cambridge	Recruiting	Observational	United Kingdom	2023-05
Delirium Identification in Older Patients With Alzheimer's and Other Related Dementias In the Emergency Department NCT06326424 · Ohio State University	Recruiting	Observational	United States	2024-04
Diagnostic Evaluation of Dementia with Lewy Bodies Using a Multimodal Approach NCT06068361 · Assistance Publique - Hôpitaux de Paris	Recruiting	Observational	France	2024-09
ALS Research Collaborative NCT06885918 · ALS Therapy Development Institute	Recruiting	Observational	United States	2014-09
Discovery and Validation of Protein Structural Complexes in Circulating Biofluids As Novel Biomarkers for Early Diagnosis, Prognosis and Therapeutic Management of Patients Affected by Neurodegenerative Disorders NCT06803784 · Neuromed IRCCS	Recruiting	Observational	Italy	2025-02
Efficacy and Safety of Dimethyl Fumarate Among Patients with Mild Cognitive Impairment and Dementia Due to Alzheimer's Disease NCT06850597 · Medical University of Lodz	Recruiting	Interventional · Phase 2	Poland	2024-10
Fundus Camera Module for Early Detection of Alzheimer's Disease NCT06841848 · I.R.C.C.S. Fondazione Santa Lucia	Recruiting	Observational	Italy	2023-05
A Longitudinal Study to Explore the Impact of Gut Microbiome on Brain Health in Alzheimer's Disease NCT06837272 · Jining Medical University	Recruiting	Observational	China	2024-01
CPAP Randomized Controlled Trial NCT06773416 · Sunnybrook Health Sciences Centre	Not yet recruiting	Interventional	Canada	2025-02
Identification of Neuroinflammation and Neuroimaging Biomarkers Through Data Driven Artificial Intelligence Techniques for Unraveling the Heterogeneity of Aged Subjects at Risk of Dementia and to Better Inform Prevention Strategies NCT06746909 · IRCCS Fondazione Stella Maris	Recruiting	Interventional	Italy	2022-02
A Study of the Behavioral Variant of Frontotemporal Dementia and Bipolar Disorder: a Neuroimaging and Epigenetics Integrated Approach NCT06706687 · Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico	Recruiting	Interventional	Italy	2021-05
Artificial Intelligence in Molecular Imaging: Predicting Parkinson's Risk in REM Sleep Behavior Disorder NCT06629207 · Insel Gruppe AG, University Hospital Bern	Recruiting	Interventional	Switzerland	2024-10
Study on Aging and Cognitive Impairment in China NCT06679296 · First Affiliated Hospital of Wenzhou Medical University	Recruiting	Observational	China	2024-11
TAS Test: Online Motor-cognitive Tests for Early Detection of Alzheimer's Disease NCT05194787 · University of Tasmania	Recruiting	Observational	Australia	2021-03
Taiwan Geriatric Study for Dementia Risk Prevention and Cognitive Enhancement by Multi-modal Intervention NCT05407857 · Taipei Medical University Shuang Ho Hospital	Recruiting	Interventional	Taiwan	2022-07
Phase I Human Analytics (HALO) Study NCT05423860 · HALO Diagnostics	Recruiting	Observational	United States	2022-03
PUMCH Dementia Longitudinal Cohort Study NCT05023564 · Peking Union Medical College Hospital	Recruiting	Observational	China	2020-12

Full, filterable list: search ClinicalTrials.gov.

How to use this list

Open a study to see who can take part (age, diagnosis, previous treatment) and the contact details of the study team.
Interventional studies test a tool or treatment; observational studies collect data, for example to develop or check an AI model.
Phase applies to medicines; many AI and device studies show "not applicable".
Status, dates and titles are shown as the study sponsors registered them; check the study page for the latest status.
Ask your doctor whether a study fits your situation before you apply.

Source: ClinicalTrials.gov (U.S. National Library of Medicine). Search: condition "Alzheimer Disease OR Dementia" with terms for artificial intelligence, machine learning, deep learning, large language model or neural network; status recruiting or not yet recruiting. Healthcare with AI is not involved in any of these studies.