AI clinical trial finder / Colorectal (bowel) cancer

AI clinical trials in colorectal (bowel) cancer: open or opening soon

77 studies that use artificial intelligence or machine learning and are recruiting or about to recruit, from ClinicalTrials.gov (updated 2026-11-05).

Before you contact a study: a listing here is not a recommendation. Check the eligibility criteria and contacts on the official ClinicalTrials.gov page, and discuss any trial with your own doctor. Taking part is voluntary, and you can usually leave a study at any time.

Most common countries with study sites

China (18)United States (18)Italy (9)Spain (7)France (4)Japan (3)Norway (2)Germany (2)United Kingdom (2)Denmark (1)Chile (1)Brazil (1)Hong Kong (1)South Korea (1)Greece (1)

Studies

Study	Status	Type	Countries	Start
Artificial Intelligence to Implement Cost-saving Strategies for Colonoscopy Screening Based on in Vivo Prediction of Polyp Histology NCT06041945 · Istituto Clinico Humanitas	Recruiting	Interventional	Italy	2023-09
The French Gut-colo NCT06174233 · Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement	Recruiting	Observational	France	2024-06
Concordance Between Large Language Model and Multidisciplinary Team Recommendations in Rectal Cancer NCT07595107 · Shandong Cancer Hospital and Institute	Recruiting	Observational	China	2026-06
A Novel Multi-functional Artificial Intelligence System on Treatment Efficacy and Implementation in Colonoscopy NCT07844252 · Chinese University of Hong Kong	Not yet recruiting	Interventional	not listed	2026-10
The AIDPRO-CRC Trial NCT06645015 · Zealand University Hospital	Recruiting	Interventional	Denmark	2025-10
Effectiveness of Artificial Intelligence-Assisted Colonoscopy for Adenoma Detection in Routine Clinical Practice : a Prospective Multicenter Randomized Trial NCT07307547 · Zhejiang University	Not yet recruiting	Interventional	China	2026-09
Multidimensional Study Designed to Develop a Methodological Framework Based on MRI Data to Predict Pathological Complete Response (pCR) in Patients With Locally Advanced Rectal Cancer After Neoadjuvant Treatment NCT07404228 · Institut du Cancer de Montpellier - Val d'Aurelle	Not yet recruiting	Observational	France	2026-10
A Preregistered Multi-Cohort Evaluation of the FATHOM AI System for Molecular Testing Prioritization to Support Clinical Trial Enrollment NCT07814872 · Harvard Medical School (HMS and HSDM)	Not yet recruiting	Observational	United States	2026-09
Multimodal Artificial Intelligence for Non-Invasive Colorectal Cancer Screening Based on Holographic Biology NCT07815093 · Xiuli Zuo	Not yet recruiting	Observational	not listed	2026-10
Optical Diagnosis of Neoplasia Using Artificial Intelligence NCT07158203 · Fundacin Biomedica Galicia Sur	Not yet recruiting	Interventional	Norway, Spain	2026-10
Machine Learning-based Surgical Guidance System for Robot-assisted Rectal Surgery NCT05652361 · Technische Universität Dresden	Recruiting	Interventional	Germany	2026-02
Microbiome-based Diagnostic Tool for the Screening of Colorectal Cancer (GUILTI) NCT06738173 · Catholic University of the Sacred Heart	Recruiting	Observational	Italy	2025-02
Microbiome Testing for the Screening of Colorectal Cancer NCT06588166 · Fondazione Policlinico Universitario Agostino Gemelli IRCCS	Recruiting	Observational	Italy	2024-11
Radiogenomic Profiling of Dendritic Cells and Macrophages to Predict Recurrence in Colorectal Liver Metastasis NCT07744139 · Fondazione Policlinico Universitario Agostino Gemelli IRCCS	Not yet recruiting	Observational	not listed	2026-09
Prospective Assessment of Alignment Between Multimodal Artificial Intelligence and Multidisciplinary Team Decisions in Gastrointestinal Oncology NCT07746830 · Shanghai Minimally Invasive Surgery Center	Not yet recruiting	Observational	China	2026-08
AI-Based Stool Image Analysis for Colorectal Neoplasia Risk Assessment NCT07740122 · Servicio de Salud Metropolitano Sur Oriente	Recruiting	Observational	Chile	2026-05
Analysis of Breath Volatile Organic Compounds Using Mass Spectrometry NCT07732686 · University of Oklahoma	Not yet recruiting	Observational	United States	2026-10
COLORECTUM+ Digital System for Postoperative Quality Improvement in Colorectal Cancer NCT06685497 · RenJi Hospital	Recruiting	Interventional	China	2024-12
Development and Validation of a Colorectal Cancer Diagnostic Model NCT07692555 · Peking University Cancer Hospital & Institute	Not yet recruiting	Observational	China	2026-07
A Feasibility Study of Mass-Based Response Drug Screening to Guide Personalized Hyperthermic Intraperitoneal Chemotherapy for High-Grade Appendiceal and Colorectal Adenocarcinoma With Peritoneal Metastasis NCT07291180 · Yale University	Recruiting	Interventional	United States	2026-02
A Noninvasive and Screening miRNA Signature for Gastrointestinal Cancer NCT07224750 · City of Hope Medical Center	Recruiting	Observational	United States	2024-06
Early Detection of Advanced Adenomas and Colorectal Cancer NCT06342440 · City of Hope Medical Center	Recruiting	Observational	China, Italy, Japan, Spain +1	2020-03
Early Onset Colorectal Cancer Detection NCT06342401 · City of Hope Medical Center	Recruiting	Observational	Italy, Japan, Spain, United States	2023-04
Exosome-derived Extrahepatic Metastasis Detection By Liquid Biopsy In Colorectal Cancer Liver Metastases NCT07224724 · City of Hope Medical Center	Recruiting	Observational	United States	2024-06
Splicing-based Predictive Learning for Individual Chemotherapy Evaluation in Colorectal Cancer NCT07226115 · City of Hope Medical Center	Recruiting	Observational	United States	2024-06
An Exosomal microRNA Signature for Preoperative Staging in Colon Cancer NCT07255729 · City of Hope Medical Center	Recruiting	Observational	United States	2025-01
EXoPERT EMERALD Clinical Study NCT07186296 · EXoPERT	Recruiting	Observational	United States	2025-05
Improving Prognostication in Colon Cancer NCT07673393 · Universitaire Ziekenhuizen KU Leuven	Not yet recruiting	Observational	not listed	2026-09
Artificial Intelligence-assisted Colonoscopy in the Detection and Characterization of Colorectal Lesions NCT07066046 · Instituto do Cancer do Estado de São Paulo	Recruiting	Interventional	Brazil	2025-02
The Radiation Oncology-Biology Integration Network (ROBIN) Molecular Characterization Trial (MCT) of Standard Short Course Radiotherapy for Rectal Cancer NCT05943210 · Weill Medical College of Cornell University	Recruiting	Interventional	United States	2023-05
Smart Symptom Tracking ALEX Application for Tracking and Monitoring Gastrointestinal Health, Smart Horizons Pilot Trial NCT07618273 · Mayo Clinic	Recruiting	Interventional	United States	2026-04
AI-empowered Nudge to Improve Colonoscopy Uptake (AINC) NCT07612436 · Fudan University	Not yet recruiting	Interventional	not listed	2026-05
Vitamin D in Patients With Stage I-III Colon Cancer or Resectable Colon Cancer Liver Metastases NCT02172651 · Dana-Farber Cancer Institute	Recruiting	Interventional · Early phase 1	United States	2014-07
Evaluation of a Diagnostic Test to Identify the Best Drugs for Treatment of Metastatic Colorectal Cancer NCT07171554 · Oncosyne AS	Recruiting	Interventional	Norway	2025-10
Remote Monitoring and Symptom Management Digital Application NCT07553572 · Patrick C. Johnson, MD	Recruiting	Interventional	United States	2026-04
Multi-scale Spatio-Temporal Analysis of Research Data NCT07189312 · Universidad de Granada	Recruiting	Observational	Spain	2025-02
Predicting the Efficacy of Neoadjuvant Therapy in Patients With Locally Advanced Rectal Cancer Using an AI Platform Based on Multi-parametric MRI NCT05523245 · Sixth Affiliated Hospital, Sun Yat-sen University	Recruiting	Observational	China	2022-06
A Prospective Study to Evaluate the Performance of a Real-time System in the Estimation of Colorectal Polyp Size NCT06957015 · Chinese University of Hong Kong	Recruiting	Interventional	Hong Kong	2025-05
AI-Assisted Chemotherapy Side Effect Management NCT07198581 · Incheon St.Mary's Hospital	Recruiting	Interventional	South Korea	2025-11
KIA-Korekt: Staged Unimodal-to-Multimodal AI Evaluation for Perioperative Risk Prediction in Colorectal Cancer NCT07537491 · Rene Mantke	Recruiting	Observational	Germany	2011-01
Advanced Therapies for Liver Metastases NCT04622423 · IRCCS San Raffaele	Recruiting	Observational	Italy	2019-11
Liquid Biopsy and Machine Learning for Early Colorectal Cancer, Adenomas, Lynch Cancers, and Residual Disease Detection NCT07450612 · San Raffaele University	Recruiting	Observational	Italy	2024-01
Advanced Classification of Colon Tumors From CT Scans Using Deep Learning for Optimized Treatment Decision-making. NCT07406958 · Assistance Publique - Hôpitaux de Paris	Not yet recruiting	Observational	France	2026-02
AI-Based Prediction of Liver Metastasis in Colorectal Cancer (A Retrospective Study) NCT07399236 · Tongji Hospital	Recruiting	Observational	China	2015-01
Prospective Validation of an AI Model for Predicting Liver Metastasis in Colorectal Cancer NCT07392567 · Tongji Hospital	Recruiting	Observational	China	2026-01
Role of Photon Counting CT in Detecting Liver Metastatis From Colorectal Cancer NCT06753903 · IRCCS San Raffaele	Recruiting	Observational	Italy	2025-03
COLONYVAQ™, a Quantum-Classical Guided Personalized Neoantigen Vaccine for MSS Stage III Colorectal Cancer NCT07328087 · Biogenea Pharmaceuticals Ltd.	Recruiting	Interventional · Early phase 1	Greece	2026-02
The CCANED-CIPHER Study: Early Cancer Detection and Treatment Response Monitoring Using AI-Based Platelet and Immune Cell Transcriptomic Profiling NCT06717295 · Javier Toledo	Recruiting	Observational	Argentina, Nigeria, United Kingdom	2025-12
Precision Physical Exercise for Personalized Onco-Hematology. NCT07286539 · University of Salamanca	Not yet recruiting	Interventional	not listed	2026-04
AI-assisted Integrated Care to Promote Colonoscopy Uptake NCT07261059 · Fudan University	Not yet recruiting	Interventional	not listed	2025-12
Using 4D Urinary Proteomics to Predict and Evaluate Treatment Response in Colorectal Cancer NCT06904677 · Cancer Institute and Hospital, Chinese Academy of Medical Sciences	Recruiting	Observational	China	2025-05
A Prospective, Multi-center, Observational Study for Signal-C Test Evaluation NCT06059963 · Universal Diagnostics	Recruiting	Observational	United States	2024-01
SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry NCT03452774 · Massive Bio, Inc.	Recruiting	Observational	Puerto Rico, United States	2018-01
Observational Cross-reactivity Study for Colorectal Cancer Diagnosis NCT06889844 · ADVANCED MARKER DISCOVERY S.L.	Recruiting	Observational	Spain	2023-04
Development and Validation of a Blood Test for Early Diagnosis of Colorectal Cancer NCT06889883 · ADVANCED MARKER DISCOVERY S.L.	Recruiting	Observational	Spain	2023-06
1. SAFE-AI ONCO-TRACK: Multimodal GenAI for Early Detection of Minimal Residual Disease and Recurrence in Gastrointestinal Oncology NCT07189520 · Università Politecnica delle Marche	Not yet recruiting	Observational	not listed	2026-06
3D Modeling for Detecting Locally Advanced Rectal Cancer With Positive Circumferential Resection Margin NCT07183124 · Taichung Veterans General Hospital	Not yet recruiting	Observational	Taiwan	2025-10
ScreenTalk to Improve Colorectal Cancer Screening Uptake Among First-degree Relatives of Patients: a Study Protocol NCT06710860 · Sun Yat-sen University	Not yet recruiting	Interventional	China	2025-07
Evaluating AI and Human Expert Decisions in Colorectal Cancer NCT07045207 · Peking University Cancer Hospital & Institute	Not yet recruiting	Observational	China	2025-07
Early Diagnosis and Recurrence Monitoring of Colorectal Cancer NCT06991452 · Huashan Hospital	Not yet recruiting	Observational	China	2025-05
Raman Spectroscopy-Based Deep Learning Model for Early Pan-Cancer Early Diagnosis NCT06822413 · Second Affiliated Hospital, Zhejiang University, School of Medicine	Recruiting	Observational	China	2022-09
TNT of SCRT+CAPOX vs SCRT+CAPOXIRI for Locally Advanced Rectal Cancer NCT05646511 · National Cancer Center Hospital East	Recruiting	Interventional · Phase 3	Japan	2022-11
Analysis of Circulating Tumor Markers in Blood NCT04025541 · Institut du Cancer de Montpellier - Val d'Aurelle	Recruiting	Interventional	France	2018-05
Artificial Intelligence (AI) Technology May Help Patients to Understand Bowel Preparation Better Before They go for Colonoscopy.This Study Attempts to Leverage AI Chatbot in Counselling Patients to Improve Bowel Cleanliness, Reduce Anxiety as Well as Increase Procedural Satisfaction NCT06905782 · National University of Malaysia	Not yet recruiting	Interventional	Malaysia	2025-04
Artificial Intelligence-based Screening Models for Prevention and Early Detection of Colorectal Cancer NCT06799793 · IRCCS Azienda Ospedaliero-Universitaria di Bologna	Recruiting	Interventional	Italy	2024-12
Artificial Intelligence-Assisted Colonoscopy in Colorectal Cancer Screening in a General Hospital NCT06792292 · Chirec	Not yet recruiting	Interventional	Belgium	2025-02
CLASSICA: Validating AI in Classifying Cancer in Real-Time Surgery NCT05793554 · Mater Misericordiae University Hospital	Recruiting	Observational	Ireland	2023-03
AI in Predicting Polyp Pathology and Endoscopic Classification NCT06773832 · Peking Union Medical College Hospital	Recruiting	Observational	China	2025-01
Early DiAgnosis Real-Time Healthcare System for CANcer Trial NCT05064124 · University College, London	Recruiting	Observational	United Kingdom	2024-07
Urine Metabolites in the Diagnosis of Disease NCT06710067 · Luventix, Inc.	Recruiting	Observational	United States	2024-10
The Impact of Radiotherapy on Oligometastatic Cancer NCT05933876 · Institut Investigacio Sanitaria Pere Virgili	Recruiting	Observational	Spain	2022-12
EOCRCPred: an AI Model to Predict Survival in EOCRC Patients After Surgery NCT06690606 · Shanghai University of Traditional Chinese Medicine	Not yet recruiting	Observational	China	2024-11
Evaluation of Gixam's Performance in a FIT Negative Population NCT06612281 · Jubaan Ltd.	Recruiting	Interventional · Phase 2	United States	2024-11
Evaluation of Gixam's Efficacy Predicting Pre-cancerous Colorectal Polyps and Colorectal Cancer NCT06688110 · Jubaan Ltd.	Not yet recruiting	Interventional	Netherlands	2025-02
AI-Assisted Non-Contrast CT for Multi-Cancer Screening NCT06632886 · Guo ShiWei	Recruiting	Interventional	China	2024-10
Digital Home-Based Prehabilitation Before Surgery NCT06231576 · Vestre Viken Hospital Trust	Not yet recruiting	Interventional	not listed	2024-02
Multimodal Deep Learning Signature for Evaluation of Response to Bevacizumab in Patient With Colorectal Cancer Liver Metastasis NCT05354674 · Fudan University	Not yet recruiting	Observational	China	2023-09

Full, filterable list: search ClinicalTrials.gov.

How to use this list

Open a study to see who can take part (age, diagnosis, previous treatment) and the contact details of the study team.
Interventional studies test a tool or treatment; observational studies collect data, for example to develop or check an AI model.
Phase applies to medicines; many AI and device studies show "not applicable".
Status, dates and titles are shown as the study sponsors registered them; check the study page for the latest status.
Ask your doctor whether a study fits your situation before you apply.

Source: ClinicalTrials.gov (U.S. National Library of Medicine). Search: condition "Colorectal Cancer" with terms for artificial intelligence, machine learning, deep learning, large language model or neural network; status recruiting or not yet recruiting. Healthcare with AI is not involved in any of these studies.