AI clinical trial finder / Depression and anxiety

AI clinical trials in depression and anxiety: open or opening soon

95 studies that use artificial intelligence or machine learning and are recruiting or about to recruit, from ClinicalTrials.gov (updated 2026-11-05).

Before you contact a study: a listing here is not a recommendation. Check the eligibility criteria and contacts on the official ClinicalTrials.gov page, and discuss any trial with your own doctor. Taking part is voluntary, and you can usually leave a study at any time.

Most common countries with study sites

United States (24)China (15)Turkey (Türkiye) (9)United Kingdom (6)Germany (4)France (4)Hong Kong (3)Mexico (2)Poland (2)Italy (2)Canada (2)Denmark (1)Israel (1)Macau (1)Taiwan (1)

Studies

Study	Status	Type	Countries	Start
Assessing of Behavioral Risk and Response to Electromagnetic and Psychedelic Therapies NCT07745569 · University of New Mexico	Not yet recruiting	Interventional · Phase 2	not listed	2026-12
A Prospective Study of Anxiety, Depression, and Bipolar Disorder in People NCT07903246 · Second Affiliated Hospital, Zhejiang University, School of Medicine	Recruiting	Observational	China	2026-09
Improving Women's Fertility Awareness and Reducing Anxiety Through Ovarian Reserve Screening and AI Counseling NCT07894302 · City University of Hong Kong	Recruiting	Interventional	Hong Kong	2026-03
AI-Enabled Wearable Monitoring for Detection of Postpartum Depression and Anxiety NCT07866053 · University of Hawaii	Not yet recruiting	Observational	United States	2026-12
A Study of Music Therapy for Anxiety in People With Cancer NCT07845422 · Memorial Sloan Kettering Cancer Center	Recruiting	Interventional	United States	2026-09
Effect of AI-Assisted Anatomical Visualization on Anxiety and Kinesiophobia in Knee Arthroplasty Patients NCT07545447 · Munzur University	Recruiting	Interventional	Turkey (Türkiye)	2026-08
The Effect of Virtual Reality Glasses on Vital Signs and State Anxiety in Patients Undergoing Coronary Angiography NCT07032935 · Kutahya Health Sciences University	Recruiting	Interventional	Turkey (Türkiye)	2026-05
AI-Assisted Patient Education Before Suturing in Minor Trauma NCT07872215 · Gazi University	Recruiting	Interventional	Turkey (Türkiye)	2026-10
Deep Phenotyping for Clinical Inferring Response in Treatment Resistant Depression NCT06396312 · Max-Planck-Institute of Psychiatry	Recruiting	Observational	Germany	2024-04
Digital Coach to Support Exposure Therapy Homework for Anxious Youth NCT07666672 · Massachusetts General Hospital	Not yet recruiting	Interventional	United States	2027-02
Addressing Pregnant Women's First Trimester Worries and Information Needs With mHealth Solutions NCT07114471 · Bournemouth University	Recruiting	Observational	United Kingdom	2026-03
The Efficacy of Psilocybin Therapy for Depression in Parkinson's Disease NCT07610369 · Yale University	Recruiting	Interventional · Phase 2	United States	2026-07
Neurobiological Mechanisms of Aging and Stress on Prospective Navigation NCT03896529 · Georgia Institute of Technology	Recruiting	Interventional	United States	2019-09
Singula Phase 0.1 Primary Care Pilot NCT07834684 · Singula Health, Inc.	Recruiting	Observational	United States	2026-07
Identification of Depressive and Anxiety Symptoms Among a Sample of Emergency Department Patients Using Artificial Intelligence (AI) Technology NCT06473558 · University Hospitals Cleveland Medical Center	Not yet recruiting	Interventional	United States	2027-02
A Neurosensory Account of Anxiety and Stress (Study 2) NCT07079839 · The University of Texas Health Science Center, Houston	Recruiting	Interventional	United States	2025-07
Evaluating Conversational Artificial Intelligence for Depression Management NCT07105397 · George Mason University	Recruiting	Interventional	United States	2026-07
Speech-Based Artificial Intelligence for Detection of Dementia in Danish Patients (DetectAI) NCT07200739 · Zealand University Hospital	Not yet recruiting	Observational	Denmark	2026-11
AI-Generated Personalized Story Book to Improve Patient Behaviour NCT07778134 · Eskisehir Osmangazi University	Recruiting	Interventional	Turkey (Türkiye)	2026-06
Home-Based Wearable rTMS Therapy for Moderate to Severe Depression NCT07775586 · Shanghai Mental Health Center	Not yet recruiting	Interventional	China	2026-08
AI-Based Personalized Exercise Prescription Through Mobile Health on Physical Activity and Health Outcomes in Older Adults: A Feasibility Study NCT07768670 · The University of Tennessee, Knoxville	Recruiting	Interventional	United States	2026-10
CODEPAD-III (Collaborative Outcomes of DEpression and Pain Associated With Delivery-III) NCT07773259 · KK Women's and Children's Hospital	Not yet recruiting	Interventional	not listed	2026-10
Physician vs Artificial Intelligence Counseling Before Elective Cesarean Delivery: A Randomized Controlled Trial NCT07762534 · Wolfson Medical Center	Not yet recruiting	Interventional	Israel	2026-08
Multimodal Biomarkers and Precision TMS for Postpartum Depression NCT07757815 · University of Macau	Not yet recruiting	Interventional	Macau	2026-09
Postpartum Education Via Artificial Intelligence for Recovery and Loneliness: A Randomized Controlled Trial NCT07223736 · University of California, San Diego	Recruiting	Interventional	United States	2026-01
Prediction on the Recurrence of Manic and Depressive Episodes in Bipolar Disorder NCT05828056 · National Taiwan University Hospital	Recruiting	Observational	Taiwan	2020-03
Using Machine Learning to Optimize User Engagement and Clinical Response to Digital Mental Health Interventions NCT05567640 · Boston University Charles River Campus	Recruiting	Interventional	United States	2023-04
StratCare Trial 2: Evaluating the Clinical and Cost-effectiveness of AI-driven Stratified Care for Depression NCT06567340 · Rotherham Doncaster and South Humber NHS Foundation Trust	Recruiting	Interventional	United Kingdom	2025-06
RECOVERS - Realigning Emotion and COgnition Via prEcision Regulation networkS NCT05977439 · Medical University of South Carolina	Recruiting	Interventional	United States	2024-02
Effect of AI-Assisted Expressive Writing on Anxiety, Emotional Distress, and Quality of Life Among Patients Receiving Chemotherapy NCT07713381 · Alexandria University	Not yet recruiting	Interventional	Egypt	2026-07
Feasibility and Implementation of Early Referral in Perinatal Mental Health NCT07609550 · University of Seville	Recruiting	Interventional	Spain	2026-07
The Impact of Enhanced Music & Natural Visuals on Emotional Health NCT07676110 · soundBrilliance LLC	Recruiting	Interventional	United States	2026-05
Sham-Controlled Rapid-Acting Neuromodulation for Depression NCT07487454 · University of California, Davis	Not yet recruiting	Interventional	United States	2026-12
Investigating the Efficacy and Mechanisms of Individualized tACS Targeting Anhedonia in Late-Life Depression NCT07637773 · Jie Li	Recruiting	Interventional	China	2026-03
Personalized AI-Driven Models in Cognitive Behavioral Therapy for Anxiety NCT07430800 · University of Southern California	Recruiting	Interventional	United States	2026-03
Impact of a Novel Functional Snack on Perimenopausal Symptoms and Well-being NCT07599930 · King's College London	Recruiting	Interventional	United Kingdom	2026-04
The Impact of AI-Powered Training on Gynecological Examination Anxiety and Satisfaction NCT07599358 · Fenerbahce University	Not yet recruiting	Interventional	not listed	2026-05
Co-designing Adaptations of a Digital Mental Health Intervention (Wysa) for Adolescent Girls With Anxiety or Depression in Rural India NCT07595029 · Wysa	Not yet recruiting	Observational	not listed	2026-05
NLP Analysis of Weekly Narratives for Dynamic Clinical Assessment in SUD NCT07595614 · Lauro Gutiérrez Castro	Recruiting	Observational	Mexico	2025-05
AI-GF-GNW on Prolonged Grief Reactions NCT07589088 · Peking University	Not yet recruiting	Interventional	China	2026-05
Psychosocial Effects of a Trauma-Informed Artificial Intelligence-Supported Chatbot in Adults Newly Diagnosed With Cancer NCT07583069 · Koç University	Not yet recruiting	Interventional	not listed	2026-07
AcceXible Speech-Based Screening for Depression and Anxiety in University Students (UAQ, Mexico) NCT07578142 · Accexible	Not yet recruiting	Observational	Mexico	2026-09
AI-Guided CBT for Depression and Anxiety NCT07576686 · Aleksandra Stojanovic	Recruiting	Interventional	Serbia	2026-01
Optimization of Late Imagery Rescripting Research Using Generative Artificial Intelligence NCT07565714 · University of Social Sciences and Humanities, Warsaw	Recruiting	Interventional	Poland	2026-04
Clinical and Objective Psychiatric Analyses in Severe Depression. NCT06095310 · University Hospital, Lille	Recruiting	Interventional	France	2023-11
Biomarkers of ASD/ADHD and Factors Affecting Anxiety and Depression in Children and Young Adults NCT07570381 · University of Exeter	Not yet recruiting	Observational	United Kingdom	2026-08
PARO-agitation-study NCT07568093 · Hannover Medical School	Recruiting	Interventional	Germany	2025-12
Impact of Play Interventions on Stress and Anxiety Using EEG and AI. NCT07555158 · Universidad Autonoma de Baja California	Not yet recruiting	Interventional	not listed	2026-08
Comparison of Patient Understanding and Anxiety According to the Delivery Method of Educational Videos NCT07550686 · Yonsei University	Recruiting	Interventional	South Korea	2025-12
Phenotypic Exploration During Sensory Stimulation in an Acoustic Chamber NCT07544563 · Centre Hospitalier St Anne	Recruiting	Observational	France	2025-12
Development and Multicenter Validation of an AI-Based Remote Photoplethysmography (rPPG) Facial Scan for Multimodal Health Assessment NCT07491978 · Tarumanagara University	Not yet recruiting	Observational	not listed	2026-04
Functional Magnetic Resonance Imaging Study of Inhibitory Control in Bipolar Disorder and Major Depressive Disorder NCT07503275 · CHU de Reims	Not yet recruiting	Interventional	France	2026-06
CABG-AI-Supported Discharge Education NCT07503678 · Hasan Kalyoncu University	Not yet recruiting	Interventional	not listed	2026-06
Neurosurgical Outcome Network NCT06724029 · Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta	Recruiting	Observational	Italy	2022-12
AI Avatar Video vs. Tell-Show-Do for Reducing Anxiety and Improving Cooperation in Children During Local Anesthesia NCT07449884 · Saint-Joseph University	Recruiting	Interventional	Lebanon	2026-02
Speech-to-speech Voice-cloning Care (SVCC) to Improve ICU-acquired Anxiety for Critically Ill Patients NCT06743321 · Peking Union Medical College Hospital	Not yet recruiting	Interventional	China	2026-08
Non-Invasive Detection and Preservation of Neurocognitive Signals in the Peri-Death Period Using Brain-Computer Interface and Artificial Intelligence NCT07477028 · Noah Tech, Corp.	Not yet recruiting	Observational	not listed	2026-09
Neurostimulation Versus Therapy for Problems With Emotions NCT05712057 · Duke University	Recruiting	Interventional	United States	2023-05
Intracranial Investigation of Neural Circuity Underlying Human Mood NCT05871372 · Baylor College of Medicine	Recruiting	Interventional	United States	2023-07
Evaluating the Impact AI Avatar-led Mental Health Interventions for Keeping Employees in Work NCT07436117 · University of Roehampton	Recruiting	Interventional	United Kingdom	2025-10
Real-World NeuroModulate: Investigating Non-Invasive Brain Stimulation for Neuropsychiatric Disorders at TUM NCT07420322 · Technical University of Munich	Recruiting	Observational	Germany	2024-08
Construction and Clinical Validation Study of a Prediction Model for Depression After Ischemic Stroke NCT07294274 · Min Su	Recruiting	Observational	China	2025-11
Dynamic Airway Resistance & ML: Guide Sputum Suction in Ventilated Patients NCT07375667 · Affiliated Hospital of Nantong University	Recruiting	Interventional	China	2025-10
Prediction of Anxiety and Memory State NCT06551090 · Columbia University	Recruiting	Interventional	United States	2024-07
The Effects of Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) on Anxiety Responses and Emotional Regulation NCT07369908 · University of Electronic Science and Technology of China	Recruiting	Interventional	China	2025-10
An AI-Assisted Art Therapy Co-Creation Intervention NCT07362615 · Gazi University	Not yet recruiting	Interventional	not listed	2026-01
Tracking AI/LLM Literacy and Knowledge in Urology Outpatients (TALK-U) NCT07325617 · Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital	Not yet recruiting	Observational	Turkey (Türkiye)	2026-01
Validation of the Accuracy of an AI-Based System for Diagnosing Depressive Disorders NCT07311668 · Shanghai Mental Health Center	Not yet recruiting	Observational	China	2026-02
Validation of the Accuracy of an AI-Based System for Diagnosing Anxiety Disorders NCT07311655 · Shanghai Mental Health Center	Not yet recruiting	Observational	China	2026-02
The Relationship Between Quality of Life, Anxiety Levels, and Attitudes Toward Artificial Intelligence Among Women Undergoing Infertility Treatment NCT07308561 · Acibadem University	Recruiting	Observational	Turkey (Türkiye)	2025-10
An Empirical Study on the Mechanisms of Biopsychosocial Functional Improvement in Patients With Major Depressive Disorder Through Nature-Based Tourism Activities NCT07180342 · Shandong Provincial Hospital	Recruiting	Interventional	China	2025-10
Precision Subclassification of Mental Health in Diabetes: Digital Twins for Precision Mental Health to Track Subgroups NCT07212075 · Forschungsinstitut der Diabetes Akademie Mergentheim	Recruiting	Observational	Germany	2025-01
Vascular mEchanisms in, Stroke, dePression, dementiA, and deliRum: The VESPAR Project NCT05649800 · University of Leicester	Recruiting	Observational	United Kingdom	2023-03
Expansion and Evaluation of AI-generated Clinical Assessment (AI-COA®) of Depression and Anxiety Severity NCT06923995 · Deliberate Solutions Inc.	Recruiting	Interventional	United States	2025-09
Mapping and Modulating the Spatiotemporal Dynamics of Socio-Affective Processing NCT05418894 · Baylor College of Medicine	Recruiting	Interventional	United States	2022-04
Orexin Antagonism for Suicide Risk: A Proof-of-Concept Clinical Trial NCT06854224 · Marianne Goodman	Recruiting	Interventional · Phase 2	United States	2025-09
Optimization of Imagery Rescripting Research Using Generative Artificial Intelligence NCT07189715 · University of Social Sciences and Humanities, Warsaw	Recruiting	Interventional	Poland	2025-06
Effects of Artificial Intelligence Nurse Orientation Program on Psychological Outcomes and Length of Hospital Stay in Intensive Care Unit NCT07171944 · Koç University	Not yet recruiting	Interventional	Turkey (Türkiye)	2025-11
A Neurosensory Account of Anxiety and Stress (Study 1) NCT05895006 · The University of Texas Health Science Center, Houston	Recruiting	Interventional	United States	2022-04
The Effectiveness of NeuroBot in Alleviating Anxiety of Patients Undergoing Neurovascular Surgeries NCT07144540 · Chinese University of Hong Kong	Not yet recruiting	Interventional	Hong Kong	2025-10
Relevance of a Telemedicine Monitoring in the Management of Depression NCT06076317 · Assistance Publique - Hôpitaux de Paris	Recruiting	Interventional	France	2024-05
EGR2 and NLRP3 Pathways in Obstructive Sleep Apnea-Related Cognitive and Mood Disorders NCT07120711 · Xinhua Hospital, Shanghai Jiao Tong University School of Medicine	Recruiting	Observational	China	2025-07
Multimodal Identification of Depressive Symptoms in the Elderly NCT07112118 · Wuhan Mental Health Centre	Not yet recruiting	Observational	China	2025-09
DIALOG: Understanding Disorganisation: A Language-focused Global Initiative in Psychosis NCT06978465 · Douglas Mental Health University Institute	Not yet recruiting	Observational	Canada	2025-05
COntact RElationship in Neonatal Intensive Care Unit NCT06462638 · Istituto per la Ricerca e l'Innovazione Biomedica	Recruiting	Observational	Italy	2024-11
The Effect of Educational Animation on Anxiety and Fear in Children With Tympanostomy Tube Placement in Pediatric Surgery: A Randomized Controlled Trial NCT06912243 · Bartın Unıversity	Recruiting	Interventional	Turkey (Türkiye)	2024-11
Artificial Intelligence (AI) Technology May Help Patients to Understand Bowel Preparation Better Before They go for Colonoscopy.This Study Attempts to Leverage AI Chatbot in Counselling Patients to Improve Bowel Cleanliness, Reduce Anxiety as Well as Increase Procedural Satisfaction NCT06905782 · National University of Malaysia	Not yet recruiting	Interventional	Malaysia	2025-04
Depressive Symptoms After Cardiac Surgery NCT06706323 · Roland von Känel	Recruiting	Observational	Switzerland	2024-11
The Impact of AI- Supported Education in Mastectomy Patient NCT06796166 · Bezmialem Vakif University	Recruiting	Interventional	Turkey (Türkiye)	2024-08
Digital Interventions for Adults with Treatment-Resistant Depression: a Pilot Study NCT06732089 · Unity Health Toronto	Recruiting	Observational	Canada	2024-12
TDCS Interventions for Subthreshold Depressive Symptoms in Young Individuals. NCT06294184 · Guangzhou Psychiatric Hospital	Recruiting	Interventional	China	2023-11
Assessing the Impact of VR-Based Observational Mindfulness Meditation on Stress Reduction in Adults NCT06704282 · Penn State University	Not yet recruiting	Interventional	United States	2024-11
Identifying Local Field Potential Biomarkers for Treatment-Resistant Major Depression With Deep Brain Stimulation NCT06542094 · West China Hospital	Recruiting	Interventional	China	2024-08
rTMS Response Trajectories in Depression NCT03348761 · Chinese University of Hong Kong	Recruiting	Interventional	Hong Kong	2015-08
Testing a Precision Psychotherapy System for Low-income Patients NCT05118594 · National Council of Scientific and Technical Research, Argentina	Not yet recruiting	Interventional	not listed	2026-02

Full, filterable list: search ClinicalTrials.gov.

How to use this list

Open a study to see who can take part (age, diagnosis, previous treatment) and the contact details of the study team.
Interventional studies test a tool or treatment; observational studies collect data, for example to develop or check an AI model.
Phase applies to medicines; many AI and device studies show "not applicable".
Status, dates and titles are shown as the study sponsors registered them; check the study page for the latest status.
Ask your doctor whether a study fits your situation before you apply.

Source: ClinicalTrials.gov (U.S. National Library of Medicine). Search: condition "Depression OR Anxiety Disorders" with terms for artificial intelligence, machine learning, deep learning, large language model or neural network; status recruiting or not yet recruiting. Healthcare with AI is not involved in any of these studies.