AI clinical trial finder / Eye diseases

AI clinical trials in eye diseases: open or opening soon

34 studies that use artificial intelligence or machine learning and are recruiting or about to recruit, from ClinicalTrials.gov (updated 2026-11-05).

Before you contact a study: a listing here is not a recommendation. Check the eligibility criteria and contacts on the official ClinicalTrials.gov page, and discuss any trial with your own doctor. Taking part is voluntary, and you can usually leave a study at any time.

Most common countries with study sites

United States (7)Germany (4)China (4)France (3)Austria (3)Australia (2)South Korea (2)Greece (2)Taiwan (2)Slovenia (2)Spain (2)Switzerland (2)United Kingdom (2)Argentina (1)India (1)

Studies

Study	Status	Type	Countries	Start
Age-Related Macular Degeneration Benchmark Imaging Dataset (ABID) NCT06924021 · University of Wisconsin, Madison	Recruiting	Observational	Argentina, Australia, Germany, India +3	2025-05
Leveraging Artificial Intelligence to Prevent Vision Loss From Diabetes NCT06763952 · University of Wisconsin, Madison	Recruiting	Interventional	United States	2026-10
A Multicenter Randomized Double-Blind Trial of Chrocare CDSS for Integrated Management of Type 2 Diabetes NCT07833228 · Shanghai Jiao Tong University School of Medicine	Not yet recruiting	Interventional	China	2026-10
GlaukomAI: Clinical Validation of an AI System for Early Glaucoma Screening NCT07668193 · Fondazione G.B. Bietti, IRCCS	Not yet recruiting	Interventional	not listed	2026-10
The Glaucoma and Retinopathy Screening Study NCT06882356 · Massachusetts Eye and Ear Infirmary	Recruiting	Interventional	United States	2025-07
Validation of the Artificial Intelligence Subsystem of the DDART Medical Device for the Automated Detection of Lesions Compatible With Glaucoma in a Random Sample of Retinal Fundus Photographs NCT07758569 · Democritus University of Thrace	Recruiting	Observational	Greece	2026-04
Validation of the Artificial Intelligence Subsystem of the DDART Medical Device for the Automated Detection of Lesions Compatible With Diabetic Retinopathy in a Random Sample of Retinal Fundus Photographs NCT07758582 · Democritus University of Thrace	Recruiting	Observational	Greece	2026-05
AI Screening for Diabetic Retinopathy NCT05704491 · West German Center of Diabetes and Health	Recruiting	Observational	Germany	2023-01
Effectiveness and Cost-Effectiveness Evaluations of AI-Assisted Diagnostic Software (VeriSee) for Ophthalmic Disease Screening NCT06843499 · National Taiwan University Hospital	Recruiting	Interventional	Taiwan	2025-06
Artificial Intelligence-Aided Screening for Patients With Diabetic Retinopathy and Age-related Macular Degeneration in Family Medicine and Geriatric Medicine Outpatient Clinics NCT07069647 · National Taiwan University Hospital	Recruiting	Interventional	Taiwan	2025-10
Pediatric Artificial Intelligence for Retinopathy Screening in Children With Type 1 Diabetes NCT07149142 · University Hospital, Motol	Recruiting	Interventional	Czechia	2026-07
An Open-label Safety, Tolerability and Exploratory Efficacy Clinical Trial of PST-611 in Geographic Atrophy NCT07705568 · Eyevensys	Not yet recruiting	Interventional · Phase 2	France	2026-09
A Phase 2, Randomized, Placebo Controlled, Multicenter, Masked Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacodynamics of Multidose APL 3007 in Combination With Syfovre/Pegcetacoplan (APL-2) in Patients Diagnosed With Geographic Atrophy Secondary to Age Related Macular Degeneratio NCT07215390 · Apellis Pharmaceuticals, Inc.	Recruiting	Interventional · Phase 2	United States	2025-06
AI vs. Physician for Anti-VEGF Decision-Making: An RCT NCT07328776 · Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine	Not yet recruiting	Interventional	China	2026-05
Defining Retinal Structures Using Hyperspectral Retinal Imaging NCT07555574 · Center for Eye Research Australia	Recruiting	Interventional	Australia	2025-01
Clinical Efficacy of Implementing an AI-SaMD for Funduscopy Analysis in Patients With Diabetes Mellitus NCT07378956 · VUNO Inc.	Recruiting	Interventional	South Korea	2026-04
Artificial Intelligence-assisted Diagnosis in Ophthalmology NCT07497815 · Marisse Masis-Solano	Not yet recruiting	Observational	Costa Rica	2026-05
Early Percutaneous Transluminal Angioplasty in Diabetic Foot Syndrome (PTA-DFS) NCT06124586 · Heinrich-Heine University, Duesseldorf	Recruiting	Interventional	Germany	2024-02
Glaucoma Screening Using Artificial Intelligence Assisted Clinical Model in Singapore's Diabetic Eye Screening Program NCT07243665 · Singapore Eye Research Institute	Recruiting	Interventional	Singapore	2025-11
Implementing AI-based Glaucoma Screening Within Federally Qualified Health Centers NCT06629649 · University of Alabama at Birmingham	Recruiting	Interventional	United States	2025-10
Assessment of AI Program 'DRISTi' as a Screening Tool NCT07222293 · Artelus AI	Recruiting	Observational	United States	2025-11
High-throughput Large-model-based AI-assisted Diagnosis Using OCT NCT07249307 · Peking Union Medical College Hospital	Not yet recruiting	Observational	not listed	2025-11
Artificial Intelligence for Diagnosing Diabetic Retinopathy in Primary Care NCT07236879 · Hospital de Clinicas de Porto Alegre	Recruiting	Interventional	Brazil	2024-08
Pivotal Trial of Automated Artificial Intelligence (AI) Based System for Early Diagnosis of Diabetic Retinopathy NCT07151001 · iHealthScreen Inc	Recruiting	Observational	United States	2025-01
"My Eyes, My Light": Amar Chokh, Amar Alo NCT07135570 · Data Yakka, Inc.	Recruiting	Observational	Bangladesh	2025-01
Research on a New Intelligent Mobile Screening and Diagnosis Pattern for Ocular Diseases NCT07003165 · Zhongshan Ophthalmic Center, Sun Yat-sen University	Not yet recruiting	Observational	not listed	2025-07
Personalized Monitoring of Non-foveal, Non-vision Compromising Atrophic Age-related Macular Degeneration With Artificial Intelligence and Identification of Disease Progression NCT06351657 · Medical University of Vienna	Recruiting	Observational	Austria, France, Slovenia, Spain +2	2025-04
Personalised Monitoring of Early and Intermediate Age-related Macular Degeneration With Artificial Intelligence and Identification of Disease Progression NCT06351670 · Medical University of Vienna	Recruiting	Observational	Austria, France, Slovenia, Spain +2	2025-02
Evaluation of Clinical Progression, Prognostic Factors, and Quality of Life in Patients with Age-related Macular Degeneration. NCT06899360 · University of Udine	Recruiting	Observational	Italy	2024-10
Assessing of Artificial Intelligence-based Software Platform for Diabetic Retinopathy Screening NCT06879834 · The Filatov Institute of Eye Diseases and Tissue Therapy	Recruiting	Observational	Ukraine	2024-11
This Project At LMU Looks At How Using AI 2nd Opinion Report to Analyze Retinal Eye Scans Impact Doctors' Decisions About Treatment for Patients with a Specific Eye Disease (nAMD) NCT06817915 · Johannes Schiefelbein	Not yet recruiting	Interventional	Germany	2025-01
Prospective Cohort Study on Predicting the Progression of Diabetic Microangiopathy Using Multimodal Eye Imaging NCT06727955 · Peking University Third Hospital	Not yet recruiting	Observational	China	2025-01
Treatment of Neovascular AMD: Artificial Intelligence in Real-world Setting NCT05093374 · Medical University of Vienna	Recruiting	Interventional · Phase 4	Austria	2021-03
The Diabetic Retinopathy Screening, Prevention and Control Program NCT04240652 · Shanghai Jiao Tong University School of Medicine	Recruiting	Observational	China	2018-06

Full, filterable list: search ClinicalTrials.gov.

How to use this list

Open a study to see who can take part (age, diagnosis, previous treatment) and the contact details of the study team.
Interventional studies test a tool or treatment; observational studies collect data, for example to develop or check an AI model.
Phase applies to medicines; many AI and device studies show "not applicable".
Status, dates and titles are shown as the study sponsors registered them; check the study page for the latest status.
Ask your doctor whether a study fits your situation before you apply.

Source: ClinicalTrials.gov (U.S. National Library of Medicine). Search: condition "Diabetic Retinopathy OR Glaucoma OR Macular Degeneration" with terms for artificial intelligence, machine learning, deep learning, large language model or neural network; status recruiting or not yet recruiting. Healthcare with AI is not involved in any of these studies.