AI clinical trial finder / Lung cancer

AI clinical trials in lung cancer: open or opening soon

108 studies that use artificial intelligence or machine learning and are recruiting or about to recruit, from ClinicalTrials.gov (updated 2026-11-05).

Before you contact a study: a listing here is not a recommendation. Check the eligibility criteria and contacts on the official ClinicalTrials.gov page, and discuss any trial with your own doctor. Taking part is voluntary, and you can usually leave a study at any time.

Most common countries with study sites

China (36)United States (22)France (8)Italy (5)Hong Kong (3)Canada (3)United Kingdom (3)Denmark (2)Taiwan (2)Germany (2)Spain (2)Kuwait (1)Brazil (1)Norway (1)Vietnam (1)

Studies

Study	Status	Type	Countries	Start
A Study to Screen for Lung Cancer in High-risk Individuals Who Have Never Smoked Using Low-dose Computed Tomography (LDCT). NCT07914881 · AstraZeneca	Not yet recruiting	Observational	not listed	2026-11
Feasibility and Uptake of Low-Dose CT Lung Cancer Screening in Kuwait NCT07766538 · Sulaiman Khadadah	Recruiting	Interventional	Kuwait	2026-09
Using an Artificial Intelligence Software Tool (iSeg) During Radiation Treatment Planning for Patients With Lung Tumors NCT07898241 · Northwestern University	Not yet recruiting	Interventional	United States	2027-02
Longitudinal AI-Assisted Management of Indeterminate Pulmonary Nodules NCT07895277 · Union Hospital, Tongji Medical College, Huazhong University of Science and Technology	Recruiting	Interventional	China	2025-01
Label-free Femtosecond Laser Imaging Combined With the Fast Lung Artificial Intelligence Model for Rapid Intraoperative Diagnosis of Lung Surgical Specimens: A Multicentre, Prospective, Parallel-workflow, Non-inferiority Study. NCT07681245 · Shanghai Chest Hospital	Recruiting	Observational	China	2026-07
Observational Study That Will Analyse the Spread and Stratification of Lung Cancer Risk Using Artificial Intelligence NCT07617636 · AstraZeneca	Not yet recruiting	Observational	Brazil	2026-12
Lung Cancer Detection in Never Smokers Using Urine Volatile Organic Compound (VOCs) NCT07871656 · Thomas Jefferson University	Recruiting	Observational	United States	2026-09
Study of Collection and Analysis of Clinical, Anamnestic, Functional, Biological Data Through the Support of Artificial Intelligence to Evaluate the Possibility of Defining a Digital Twin of the Lung (LUCE) NCT07517393 · Casa di Cura Dott. Pederzoli	Recruiting	Observational	Italy
Postoperative Pulmonary Function Assessment Based on Deep Learning Study NCT07256457 · Chinese University of Hong Kong	Not yet recruiting	Interventional	Hong Kong	2026-11
Diagnostic Performance of an AI-Based Multi-Omics Model for Early Lung Cancer NCT07882628 · Beijing Chao Yang Hospital	Not yet recruiting	Observational	China	2026-10
Benchmarking Large Language Models Against Tumour Boards for Oncology Treatment Recommendations NCT07739121 · Assistance Publique - Hôpitaux de Paris	Recruiting	Observational	France	2026-05
AI-Assisted 3D Reconstruction for Lung Resection Planning NCT07853157 · S. Andrea Hospital	Not yet recruiting	Observational	Italy	2026-11
Integrating Artificial Intelligence Into Lung Cancer Screening. NCT05704920 · Centre Hospitalier Universitaire de Nice	Recruiting	Interventional	France	2024-04
Radiomics for Distinguishing Benign and Malignant Lung Nodules NCT07852000 · Assiut University	Not yet recruiting	Observational	not listed	2026-10
Risk-Based Lung Cancer Detection in COPD Patients NCT07848815 · Vejle Hospital	Recruiting	Interventional	Denmark	2026-06
Augmented Endobronchial Ultrasound (EBUS-TBNA) With Artificial Intelligence NCT05739331 · Norwegian University of Science and Technology	Recruiting	Observational	Norway	2023-05
AI-Assisted Management of Pulmonary Nodules Found on Low-Dose CT in Health Screening NCT07841600 · The First Affiliated Hospital of Guangzhou Medical University	Not yet recruiting	Interventional	not listed	2026-10
AI-Assisted Chest CT Interpretation Across the Lung Cancer Care Continuum NCT07829640 · Union Hospital, Tongji Medical College, Huazhong University of Science and Technology	Not yet recruiting	Interventional	China	2026-09
Short- and Mid-term Therapeutic, Prognostic, and Societal Impact of Implementing Intraoperative Assessment of Pulmonary Resection Quality for Lung Cancer NCT07828938 · Fondation Hôpital Saint-Joseph	Not yet recruiting	Interventional	France	2026-09
AI-Personalized Discharge Education for Patients After Lung Cancer Surgery NCT07827183 · Xiamen University	Recruiting	Interventional	China	2026-08
Effectiveness of Chat-based Mobile Application for Consultation (Zalo) in Improving Compliance With Follow-up Tests After Abnormal Chest X-ray Findings Interpret by Artificial Intelligent NCT07234929 · Gia Dinh People Hospital	Recruiting	Interventional	Vietnam	2026-09
Multimodal AI Predicts High-risk Pathology in Lung Cancer Associated With Cystic Airspaces NCT07820423 · Central South University	Recruiting	Observational	China	2025-05
A Preregistered Multi-Cohort Evaluation of the FATHOM AI System for Molecular Testing Prioritization to Support Clinical Trial Enrollment NCT07814872 · Harvard Medical School (HMS and HSDM)	Not yet recruiting	Observational	United States	2026-09
A Multicenter Cohort Study of AI-Based Methods for Pulmonary Nodule Diagnosis and Follow-up NCT07815483 · Shanghai East Hospital	Not yet recruiting	Observational	not listed	2026-10
Exhaled Breath Electronic Nose for Multi-Disease Risk Prescreening NCT07804017 · The First Affiliated Hospital of Guangzhou Medical University	Not yet recruiting	Observational	not listed	2026-09
Staging Strategies and Their Association With Prognosis and Therapy in Lung Cancer With Cystic Airspaces NCT07066813 · Central South University	Recruiting	Observational	China	2025-06
A Multicenter Prospective Study Evaluating the Diagnostic Performance of Femtosecond Laser Label-Free Imaging Combined With Artificial Intelligence for Predicting High-Risk Pathological Features in Lung Cancer NCT07799038 · Shanghai Zhongshan Hospital	Not yet recruiting	Observational	not listed	2026-09
A Multicenter, Prospective Study on the Diagnostic Efficacy of Femtosecond Laser Label-Free Imaging Combined With Artificial Intelligence-Assisted Diagnosis for Rapid Diagnosis of Lung Cancer Surgical Specimens NCT07794449 · Shanghai Zhongshan Hospital	Not yet recruiting	Observational	not listed	2026-09
Practical Geriatric Assessment in Older Adults With Non-Small Cell Lung Cancer Undergoing Stereotactic Body Radiation Therapy NCT06987890 · Brigham and Women's Hospital	Recruiting	Interventional	United States	2025-05
LEGACY: Lung Cancer Screening in Individuals With a Lung Cancer Family History-Protocol B NCT07600801 · Massachusetts General Hospital	Recruiting	Observational	United States	2026-06
Digital Early Warning System for Acute Lung Injury in Liver Surgery NCT07070362 · Beijing Tsinghua Chang Gung Hospital	Recruiting	Observational	China	2024-11
Testing the Addition of High Dose, Targeted Radiation to the Usual Treatment for Locally-Advanced Inoperable Non-Small Cell Lung Cancer NCT05624996 · NRG Oncology	Recruiting	Interventional · Phase 3	Canada, United States	2023-07
Nitride-Based Raman Biochip for Lung Cancer Diagnosis and Monitoring NCT07755020 · Taichung Veterans General Hospital	Recruiting	Observational	Taiwan	2025-08
LUNG-07: Advancing Precision-Based Lung Cancer Screening: Implementation, AI-Guided Risk Stratification, and Biomarker Integration (CREST AI) NCT07408531 · University of Illinois Chicago	Recruiting	Interventional	United States	2026-03
The Development, Safety, and Feasibility of an Artificial Intelligence-Powered Platform (NodeAI) for Real-Time Prediction of Mediastinal Lymph Node Malignancy During Endobronchial Ultrasound Staging for Lung Cancer NCT06540196 · McMaster University	Recruiting	Interventional	Canada	2025-01
Analysis of Breath Volatile Organic Compounds Using Mass Spectrometry NCT07732686 · University of Oklahoma	Not yet recruiting	Observational	United States	2026-10
Multicenter Prospective Validation of AI Models for Malignancy Risk Prediction in Pulmonary Nodules NCT07727122 · Guangdong Provincial People's Hospital	Not yet recruiting	Observational	China	2026-07
Performance of Lung MRI Combined to Synthetic CT in the Follow-up of Lung Nodules NCT06825078 · University Hospital, Bordeaux	Recruiting	Interventional	France	2025-02
LEGACY: Lung Cancer Screening in Individuals With a Lung Cancer Family History-Protocol A NCT07685028 · Massachusetts General Hospital	Not yet recruiting	Interventional	United States	2026-10
EXoPERT EMERALD Clinical Study NCT07186296 · EXoPERT	Recruiting	Observational	United States	2025-05
Characterization of Multi-Omics Landscapes and AI Pathological Prediction Model for Long-Term Survival in NSCLC Immunotherapy NCT07668037 · Cancer Institute and Hospital, Chinese Academy of Medical Sciences	Recruiting	Observational	China	2026-05
Feasibility and Preliminary Performance of an AI Prototype for Digital ROSE During EBUS-TBNA and Peripheral TBNA: a Prospective Pilot Study (AI-ROSE-FEAS) NCT07662967 · Azienda Ospedaliera di Rilievo Nazionale A.Cardarelli	Not yet recruiting	Observational	not listed	2026-07
CHAMP Lung Cancer Screening Program NCT07572773 · Jill Kolesar	Recruiting	Interventional	United States	2026-06
Deep Learning Time-Series Prediction of Long-Term Growth Patterns of Pulmonary Ground-Glass Nodules Using Serial CT NCT07647692 · Peking University People's Hospital	Not yet recruiting	Observational	China	2026-06
ctDNA Mutations and Methylation Status for Early Detection of Lung Cancer in Patients With Suspicious Lung Nodules NCT07615556 · The University of Hong Kong	Not yet recruiting	Observational	Hong Kong	2026-06
Implementing Low-dose ct Lung Cancer Screening in France. NCT07513818 · Assistance Publique - Hôpitaux de Paris	Recruiting	Interventional	France	2026-05
Evaluating the Efficacy and Safety of AI Localization Models in Multidisciplinary Team Care for NSCLC NCT07626736 · Wen-zhao ZHONG	Recruiting	Interventional	China	2025-12
Blood Based Risk Evaluation With AI for Targeted Primary Health Care in Early Lung Cancer Detection NCT07552584 · Vejle Hospital	Recruiting	Interventional	Denmark	2026-05
Assessment of a Radiomics-based Computer-Aided Diagnosis Tool for Pulmonary nodulES NCT05968898 · Abramson Cancer Center at Penn Medicine	Recruiting	Interventional	United States	2024-01
Stereotactic Body Radiation Therapy Planning With Artificial Intelligence-Directed Dose Recommendation for Treatment of Primary or Metastatic Lung Tumors, RAD-AI Study NCT05802186 · Northwestern University	Recruiting	Interventional	United States	2023-11
Prospective Cohort Study Evaluating 18FDG PET-CT for the Early Prediction of the Efficacy of Immunotherapy Associated or Not With Chemotherapy in Patients With Locally Advanced or Metastatic Non-Small Cell Broncho-Pulmonary Carcinoma NCT06833229 · Centre Antoine Lacassagne	Recruiting	Observational	France	2022-01
Multimodal AI-Guided Recovery Management After Lung Cancer Surgery NCT07588737 · The First Affiliated Hospital of Guangzhou Medical University	Recruiting	Interventional	China	2025-03
Deep Learning Using Chest X-Rays to Identify High Risk Patients for Lung Cancer Screening CT NCT06910956 · Massachusetts General Hospital	Recruiting	Interventional	United States	2025-05
Machine Learning Approaches to Personalized Therapy for Advanced Non-small Cell Lung Cancer With Real-World Data NCT06934343 · University of Utah	Recruiting	Observational	United States	2024-09
Lung Cancer Screening for Early Detection of Suspicious Lung Nodules in Latin America(LUCAS-LATAM) NCT07524803 · Latin American Consortium for the Lung Cancer Research	Not yet recruiting	Observational	Colombia, Costa Rica	2026-05
The SENTINL-1 Study: Evaluating Patient-Reported Outcomes of AI-Inferred Lung Cancer Risk NCT07458425 · University of Illinois Chicago	Recruiting	Interventional	United States	2026-03
Lung Cancer Screening With Low-dose CT Scan in Women : Implementation Study NCT05195385 · Assistance Publique - Hôpitaux de Paris	Recruiting	Interventional	France	2022-04
Screening for Brain Metastases NCT07492121 · University of Zurich	Not yet recruiting	Interventional · Phase 2	Switzerland	2026-09
Lung Cancer Screening in HIgh Risk nonsmokErs by Artificial inteLligence Device NCT06295497 · Chinese University of Hong Kong	Recruiting	Interventional	Hong Kong	2024-07
A Hierarchical Multi-modal AI Framework for Pathological and Genetic Subtyping of Lung Cancer Based on PET/CT Imaging NCT07463300 · Second Affiliated Hospital, Zhejiang University, School of Medicine	Recruiting	Observational	China	2024-08
To Conduct Multi-omics Integrated Studies in Peripheral Blood, Such as Fragment Omics, Metabolomics and Epigenetics, and Establish Non-invasive Dynamic Follow-up Monitoring Programs During Perioperative and Postoperative Periods (Observational Study) NCT07291921 · Peking University People's Hospital	Recruiting	Observational	China	2025-05
Study of Risk Factors and Prediction of Blood Clots After Lung Cancer Surgery NCT07439991 · The First Hospital of Jilin University	Recruiting	Observational	China	2024-11
Formatting the Risk Prediction Models for Never-Smoking Lung Cancer NCT05572944 · Chung Shan Medical University	Recruiting	Observational	Taiwan	2022-12
Research on Early Screening and Diagnosis of Pulmonary Nodules Based on Novel Non-invasive Technologies. NCT07370077 · Chen KeZhong	Recruiting	Observational	China	2022-12
Immunochemotherapy, Surgery or Chemoradiation, and Durvalumab for Stage IIIA/B NSCLC NCT06810609 · University Hospital, Bonn	Recruiting	Interventional · Phase 2	Germany	2025-04
The CCANED-CIPHER Study: Early Cancer Detection and Treatment Response Monitoring Using AI-Based Platelet and Immune Cell Transcriptomic Profiling NCT06717295 · Javier Toledo	Recruiting	Observational	Argentina, Nigeria, United Kingdom	2025-12
Differentiation of Benign and Malignant Pulmonary Nodules by Volatile Organic Compounds in Human Exhaled Breath NCT06518655 · ChromX Health	Recruiting	Observational	China	2024-06
Precision Physical Exercise for Personalized Onco-Hematology. NCT07286539 · University of Salamanca	Not yet recruiting	Interventional	not listed	2026-04
Patient-centered, Optimal Integration of Survivorship and Palliative Care NCT04900935 · Massachusetts General Hospital	Recruiting	Interventional	United States	2023-09
SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry NCT03452774 · Massive Bio, Inc.	Recruiting	Observational	Puerto Rico, United States	2018-01
AI-Based DeepGEM Tool for Predicting Gene Mutations in NSCLC Patients: A Randomized Controlled Study NCT07110259 · Jianxing He	Not yet recruiting	Interventional	not listed	2025-07
Multimodal Large Model-Driven Risk and Prognosis Assessment for Brain Metastases in Lung Cancer NCT07107035 · Fudan University	Not yet recruiting	Observational	not listed	2025-09
Clinical Validation of Freenome Multiomics Blood Test for Lung Cancer Screening NCT06122077 · Freenome Holdings Inc.	Recruiting	Observational	United States	2023-11
A Study on Exploring the Abscopal Effect Induced by Different Radioimmunotherapy Combination Patterns in the Treatment of Non-Small Cell Lung Cancer With Multiple Metastases NCT06947694 · Xinqiao Hospital of Chongqing	Recruiting	Interventional · Phase 2	China	2025-07
Predicting Immunotherapy Response and Survival of Lung Cancer Patients Using Artificial Intelligence and Radiomics (Radiology-AI-Lung) NCT07059923 · Union Hospital, Tongji Medical College, Huazhong University of Science and Technology	Recruiting	Observational	China	2025-07
A Multicenter Study in Bronchoscopy Combining Stimulated Raman Histology With Artificial Intelligence for Rapid Lung Cancer Detection - The ON-SITE Study NCT07045103 · Invenio Imaging Inc.	Recruiting	Observational	United States	2023-12
The Impact of AI Assistance on Radiologist Performance and Healthcare Costs in LDCT-Based Lung Cancer Screening NCT06988579 · The First Affiliated Hospital of Guangzhou Medical University	Recruiting	Interventional	China	2024-07
AI-Based Ultrasound Prediction Model for Intracranial Pressure and Prognosis in Lung Cancer Patients With Leptomeningeal Metastasis: A Dual-Center Study NCT07005791 · The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School	Not yet recruiting	Observational	China	2025-07
Early Intervention Strategies for Lung Cancer NCT06988943 · The First Affiliated Hospital of Guangzhou Medical University	Recruiting	Interventional	China	2024-06
Cutting-edge IMAGING Technologies to Improve the SAFEty and the Sustainability of LUNG Cancer Screening and the Accuracy of Non-invasive Lung Nodules Characterization NCT06963515 · IRCCS San Raffaele	Not yet recruiting	Observational	not listed	2025-06
'SOURCE - LUNG' Stereotactic Ablative Radiation Therapy Of UltRaCEntral LUNG Tumours (SOURCE Lung) NCT04375904 · Cancer Trials Ireland	Recruiting	Interventional · Phase 2	Ireland	2020-12
DOLCE: Determining the Impact of Optellum's Lung Cancer Prediction Solution NCT05389774 · Nottingham University Hospitals NHS Trust	Recruiting	Observational	United Kingdom	2023-03
Analysis of Circulating Tumor Markers in Blood NCT04025541 · Institut du Cancer de Montpellier - Val d'Aurelle	Recruiting	Interventional	France	2018-05
SERS-Based Serum Molecular Spectral Detection of Invasive Lung Cancer NCT06775015 · Fuzhou General Hospital	Not yet recruiting	Observational	China	2026-04
SERS-Based Serum Molecular Spectral Screening for Lung Cancer Type NCT06775002 · Fuzhou General Hospital	Not yet recruiting	Observational	not listed	2026-04
SERS-Based Serum Molecular Spectral Screening for Benign and Malignant Pulmonary Proliferative Nodules NCT06775587 · Fuzhou General Hospital	Not yet recruiting	Observational	China	2026-04
SERS-Based Serum Molecular Spectral Screening for Hematogenous Metastasis NCT06772363 · Fuzhou General Hospital	Not yet recruiting	Observational	China	2026-04
Identification of Multiple Pulmonary Diseases Using Volatile Organic Compounds Biomarkers in Human Exhaled Breath NCT06528418 · ChromX Health	Recruiting	Observational	China	2024-06
Establishing a Longitudinal Cohort Study of Lung Cancer Using Tissue and Peripheral Blood Metabolomics. NCT06843707 · The First Affiliated Hospital of Guangzhou Medical University	Recruiting	Observational	China	2024-01
AI-HOPE Lung Cancer: Building a Predictive Tool for Metastatic Lung Cancer NCT06788366 · IRCCS San Raffaele	Recruiting	Observational	Italy	2024-02
Artificial Intelligence-based Model for the Prediction of Occult Lymph Node Metastasis and Improvement of Clinical Decision-making in Non-small Cell Lung Cancer NCT06684418 · Fudan University	Recruiting	Observational	China	2024-12
LcProt: Proteomics Longitudinal Cohort Study on Lung Cancer NCT06778512 · The First Affiliated Hospital of Guangzhou Medical University	Recruiting	Observational	China	2019-06
New Method to Differentiate Benign and Malignant Pulmonary Nodules. NCT06056999 · China-Japan Friendship Hospital	Recruiting	Observational	China	2023-09
Machine Learning for Predicting and Managing Quality of Life in Lung Cancer Immunotherapy Patients NCT06725225 · Second Affiliated Hospital of Zunyi Medical University	Not yet recruiting	Interventional	not listed	2025-01
A Prospective, Non-interventional Cohort Study of Subsolid Pulmonary Nodules NCT06458673 · Guangdong Provincial People's Hospital	Not yet recruiting	Observational	China	2024-12
The Impact of Radiotherapy on Oligometastatic Cancer NCT05933876 · Institut Investigacio Sanitaria Pere Virgili	Recruiting	Observational	Spain	2022-12
AI-guided Prognostication and Cranial Radiotherapy Optimization in EGFR-TKI-treated Non-small Cell Lung Cancer Patients With Baseline Brain Metastases NCT06604689 · Fudan University	Recruiting	Observational	China	2024-09
AI-Assisted Non-Contrast CT for Multi-Cancer Screening NCT06632886 · Guo ShiWei	Recruiting	Interventional	China	2024-10
Improving Detection of Early Lung Cancer in a Diverse Population (IDEAL) Study NCT06628102 · British Columbia Cancer Agency	Recruiting	Interventional	Canada	2023-08
Development of an Artificial Intelligence Model for the Identification and Prevention of Smoking-related Diseases. NCT06626178 · Scientific Institute San Raffaele	Recruiting	Interventional	Italy	2024-10
Next Generation Chest X-Ray Tomosynthesis for Screening of Lung Cancer NCT06577883 · University of California, San Diego	Recruiting	Observational	United States	2023-11
Pulmonary Watershed Topographic Map Navigation for Lung Nodule Resection NCT06404164 · Guangdong Provincial People's Hospital	Recruiting	Interventional	China	2022-01
Validation of Rapid On-site Diagnostics in Early Stage Lung Cancer Sampling With a Higher Harmonic Generation Microscope NCT06007261 · Radboud University Medical Center	Recruiting	Observational	Netherlands	2024-01
APOLLO 11, Consortium of Italian Centers Involved in Treatment of Patients With Lung Cancer Treated With Innovative Therapies: Real World Data and Translational Reaserch NCT05550961 · Fondazione IRCCS Istituto Nazionale dei Tumori, Milano	Recruiting	Observational	Italy	2022-10
Nodule IMmunophenotyping Biomarker for Lung Cancer Early Diagnosis Study NCT05432739 · Royal Marsden NHS Foundation Trust	Recruiting	Observational	United Kingdom	2021-04
The Role of ctDNA Testing Plus AI-based Pathology in Resectable LSCC NCT05778253 · Second Xiangya Hospital of Central South University	Recruiting	Observational	China	2023-03
HSI for Intersegmental Plane Identification During Sublobar Pulmonary Resections NCT05676788 · LungenClinic Grosshansdorf	Not yet recruiting	Interventional	Germany	2023-04
I3LUNG: Integrative Science, Intelligent Data Platform for Individualized LUNG Cancer Care With Immunotherapy NCT05537922 · Fondazione IRCCS Istituto Nazionale dei Tumori, Milano	Recruiting	Observational	Greece, Israel, Spain, United States	2022-10

Full, filterable list: search ClinicalTrials.gov.

How to use this list

Open a study to see who can take part (age, diagnosis, previous treatment) and the contact details of the study team.
Interventional studies test a tool or treatment; observational studies collect data, for example to develop or check an AI model.
Phase applies to medicines; many AI and device studies show "not applicable".
Status, dates and titles are shown as the study sponsors registered them; check the study page for the latest status.
Ask your doctor whether a study fits your situation before you apply.

Source: ClinicalTrials.gov (U.S. National Library of Medicine). Search: condition "Lung Cancer" with terms for artificial intelligence, machine learning, deep learning, large language model or neural network; status recruiting or not yet recruiting. Healthcare with AI is not involved in any of these studies.